Exposure to Mould and Moisture Damage Is a Potential Risk Factor for the Development of Respiratory Diseases Opinion
Jouni Lohi,
Tiina Tuomela,
Tamara Tuuminen
Issue:
Volume 8, Issue 3, September 2020
Pages:
38-41
Received:
17 July 2020
Accepted:
3 August 2020
Published:
10 August 2020
Abstract: Adverse health effects due to indoor air moisture damage has been extensively studied already for thirty years. Expose to dampness microbiota (DM) in buildings is a risk factor for newly onset asthma and other respiratory problems. This exposure increases the rate of upper and lower respiratory tract infections because the function of the cilia cells and the integrity of mucosal layer becomes compromised. The breach of the first defense barrier of innate immunity leads to susceptibility to inhaled impurities and pathogens. Dampness and mould-associated asthma may present with several clinical peculiarities. This asthma may be resistant to treatment, the symptoms may exacerbate during periods with increased outdoor air humidity and rainfalls and this asthma may be associated with chronic obstructive pulmonary disease (COPD). It has been generally recognized that persons sensitized to DM should avoid new and repeated exposure to moldy environment. This recommendation is important especially during the current SARS-CoV2 pandemic.
Abstract: Adverse health effects due to indoor air moisture damage has been extensively studied already for thirty years. Expose to dampness microbiota (DM) in buildings is a risk factor for newly onset asthma and other respiratory problems. This exposure increases the rate of upper and lower respiratory tract infections because the function of the cilia cel...
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Immunoinformatics Design of Novel Multi-Epitope Subunit Vaccine for SARS-CoV-2 by Exploring Virus Conserved Sequences of the Spike Glycoproteins
Itemobong Ekaidem,
Anietie Moses,
Youtchou Tatfeng
Issue:
Volume 8, Issue 3, September 2020
Pages:
42-52
Received:
6 July 2020
Accepted:
21 July 2020
Published:
27 October 2020
Abstract: Sars-CoV-2 infection also called COVID-19 is characterized by fever and signs of acute respiratory distress syndrome (ARDS). It is currently a global pandemic with high mortality rate in those with severe disease. Lack of effective vaccine and approved drug for treatment created a disastrous condition among the global communities. This study was designed as a step ahead in the path of protein-based subunit vaccine development. The primary amino acid sequence of SARS-CoV-2 spike glycoprotein was used to design a protein subunit vaccine construct. The molecular weight of vaccine protein was 58.4 kDa with a total number of 8170 atoms and 584 amino acid residues. The theoretical pI was found to be 8.54 showing its slightly basic nature while the total number of negative and positive charged residues were 29 and 33 respectively. The peptide vaccine construct has 147 (25.17%) polar residues and 375 (64.21%) hydrophobic residues. The vaccine construct has cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL) and B cell epitopes of varying lengths having great potential to stimulate high levels of IFN-γ production. It has potent antigenic properties but lacked allergenicity. It is stable and have a good binding affinity for the TLR-4 receptor. In general, this modelling applied a series of immunoinformatics tools in a sequential manner to find an effective vaccine that may be used effectively in fighting against the COVID-19 pandemic. This modelling, however, needs real life experimental validation to prove the workability of the computational work.
Abstract: Sars-CoV-2 infection also called COVID-19 is characterized by fever and signs of acute respiratory distress syndrome (ARDS). It is currently a global pandemic with high mortality rate in those with severe disease. Lack of effective vaccine and approved drug for treatment created a disastrous condition among the global communities. This study was de...
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Induced Abortion and Its Predictors Among Hawassa University Female Students
Yohannes Fikadu Geda,
Walelign Animut Tirfe,
Molalign Mesele Gessese
Issue:
Volume 8, Issue 3, September 2020
Pages:
53-60
Received:
2 March 2020
Accepted:
19 March 2020
Published:
27 October 2020
Abstract: Global incidence of unsafe abortion among University students is increasing; and still frequent and worrisome in Universities of Ethiopia. There are a few studies on induced abortion among university students. There for this study was aimed to determine magnitude and predictors of induced abortion among Hawassa University female students. Institution based cross-sectional study was conducted from May 1-15, 2019 and 741 participants were selected from Hawassa University regular undergraduate female students. For entry and analysis EPidata and SPSS was used respectively. Association between dependent and independent variables were measured by adjusted odds ratio. Variables with p <0.25 on bivariate were used for multivariable analysis and p<0.05 were considered significant. Magnitude of induced abortion among Hawassa University students was 9.6%. From the respondents 68% of them age greater or equal to 20 (AOR=0.32, 95% CI: 0.14, 0.74) were less likely to have induced abortion compared to those respondents with age less than or equal to 19. Married respondents were 3.32 times (AOR=3.32, 95% CI: 1.51, 7.28) more likely to have induced abortion compared to not married respondents. From the respondents 95% of them who have heard only about short term contraceptive (AOR=1.95, 95% CI: 1.04, 3.66) were more likely to have induced abortion compared to those who have heard only about long term contraceptives. Respondents who have used methods to avoid pregnancy currently were 5.41 times (AOR=5.41, 95% CI: 2.73, 10.72) more likely to have induced abortion compared to who haven’t used any method. Induced abortion among Hawassa university female student was high compared to other studies. This study showed the independent predictors of abortion among Hawassa University students were age, marital status, type of contraceptive they know and using any method to avoid pregnancy currently.
Abstract: Global incidence of unsafe abortion among University students is increasing; and still frequent and worrisome in Universities of Ethiopia. There are a few studies on induced abortion among university students. There for this study was aimed to determine magnitude and predictors of induced abortion among Hawassa University female students. Instituti...
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