International Journal of Immunology

Volume 6, Issue 4, December 2018

  • BET Bromodomain Inhibition Suppresses HIF-1α-Mediated IL-17 Expression in Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis

    Youjun Xiao, Maohua Shi, Jingnan Wang, Ruiru Li, Qian Qiu, Minxi Lao, Shan Zeng, Cuicui Wang, Siqi Xu, Yaoyao Zou, Liuqin Liang, Hanshi Xu

    Issue: Volume 6, Issue 4, December 2018
    Pages: 48-57
    Received: 11 November 2018
    Accepted: 7 December 2018
    Published: 2 January 2019
    DOI: 10.11648/j.iji.20180604.11
    Abstract: Objectives: The purpose of this study was to explore the potential of the bromodomain and extra-terminal domain (BET) bromodomain to regulate IL-17 expression in peripheral blood from patients with rheumatoid arthritis (RA) and its underlying mechanisms. Methods: The level of IL-17A, TNFα and IFNγ in PBMCs from patients with RA was evaluated by a c... Show More