Abstract: Elucidation of reverse dissemination as the true mechanism by which HIV maintains chronic infection while discounting of the generally accepted model of latent reserve can open a new frontier in research that could result in radical cure. HIV may cause and maintain chronic infection by reverse disseminating from differentiating CD4 T-lymphocyte progenitor cells (LPCs) within the bone marrow niche, and that breaking the cross-infection between older and new cells can lead to elimination of the reserve infection result in radical cure. By using a mechanism that prevents the rapid expansion of HSCs that give rise to LPCs, I collected data and information from two patients that show achievement of radical cure of HIV by absence of viral resurgence for eight months after stoppage of highly active antiretroviral therapy.Abstract: Elucidation of reverse dissemination as the true mechanism by which HIV maintains chronic infection while discounting of the generally accepted model of latent reserve can open a new frontier in research that could result in radical cure. HIV may cause and maintain chronic infection by reverse disseminating from differentiating CD4 T-lymphocyte pro...Show More
