Challenges of the Control of Opportunistic Infections of Zoonotic Origin in HIV/AIDS Patients
Yemisi Olukemi Adesiji,
Julius Kola Oloke
Issue:
Volume 3, Issue 2-1, March 2015
Pages:
1-7
Received:
14 January 2015
Accepted:
19 January 2015
Published:
7 February 2015
Abstract: The HIV/AIDS pandemic is associated with a number of opportunistic infections of immunocompromised person. Some of these infections are recognized zoonoses that are naturally transmitted between animals and humans. These may be directly transmitted by, animals or indirectly by contact with contaminated food and water. Interactions between animals and humans have a complex interplay and health care providers should be aware of the potential role of animals as reservoirs of infectious diseases for HIV infected patients. The most frequent pattern of infection is characterized either by direct contact with farm or wild animals and/or ingestion of their products. Immunomodulatory antibodies that enhance the immune system to promote the function of immune cells have great promise in preventing and treating opportunistic infections of zoonotic origin in HIV/AIDS patient.
Abstract: The HIV/AIDS pandemic is associated with a number of opportunistic infections of immunocompromised person. Some of these infections are recognized zoonoses that are naturally transmitted between animals and humans. These may be directly transmitted by, animals or indirectly by contact with contaminated food and water. Interactions between animals a...
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Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients
Oloke J. K.,
Adebayo E. A.
Issue:
Volume 3, Issue 2-1, March 2015
Pages:
8-20
Received:
14 January 2015
Accepted:
19 January 2015
Published:
7 February 2015
Abstract: In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able to augment or complement a desired immune response. Such bioactive compounds are polysaccharopeptides, polysaccharide-proteins, functional proteins (ubiquinone-9, nebrodeolysin, ubiquitin-like peptide and glycoprotein), glucans, proteoglycans and many others. Most of these bioactive compounds follow the immunomodulatory pathway mechanism of polysaccharide (β-glucan) from mushrooms by stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of B-cells for antibodies production and stimulation of T-cell differentiation to T helper (Th1 and Th2) cells, which mediate cell and humoral immunities, respectively. In this review, the immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.
Abstract: In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able...
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