Volume 4, Issue 6, December 2016, Page: 73-77
The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children
Farida Tabri, Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Mochammad Hatta, Molecular Biology & Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Khaeruddin Djawad, Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab, Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi, Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Received: Dec. 8, 2016;       Accepted: Dec. 20, 2016;       Published: Jan. 19, 2017
DOI: 10.11648/j.iji.20160406.15      View  2680      Downloads  88
Abstract
Background: IL-10 is an antiinflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages. Regulatory cytokine interleukin-10 (IL-10) has been proposed as a key molecule involved in the attenuation of helminth infection and chronic inflammation, such as atopic dermatitis. The maintenance of the asymptomatic state is now recognized as reflecting an immunoregulatory environment, which may be promoted by parasites, and involves multiple levels of host regulatory cells and cytokines; currently, there is much interest in whether helminth-associated immune regulation may ameliorate allergy and autoimmunity. The objective of this study was to measure the IL-10 level in healthy person, atopic dermatitis, helminth infection and healthy persons. Methods: Levels of IL-10 was measured by ELISA technique. Kato-Katz method is used to determine the number of eggs of helminth. Results: Our study showed that those aged > 5 years old and helminth infection without atopic dermatitis had higher levels of IL-10 (3.05 ± 2.44) which was significantly higher (p < 0.001) than in children whose atopic dermatitis without the helminth infection (1.76 ± 2.72). We found that increased levels of IL-10 in helminth infection (3.05 ± 2.44) higher than healthy subjects (1.72 ± 1.74); but not statistically significant (p = 0.072). The level of IL-10 did not have significant relationship either at age ≤ 5 years old and > 5 years old in others group. Also, no correlation between egg count of helminth and level of IL-10 in serum. Conclusion: The serum of IL-10 was significantly higher in children > 5 years with helminth infection without atopic dermatitis than children with atopic dermatitis.
Keywords
Interleukin-10, Atopic dermatitis, Helminth Infection
To cite this article
Farida Tabri, Mochammad Hatta, Khaeruddin Djawad, Siswanto Wahab, Ilhamjaya Patellongi, The Relationship Between Serum Level of Interleukin-10 and State of the Disease with Atopic Dermatitis and Helminth in Children, International Journal of Immunology. Vol. 4, No. 6, 2016, pp. 73-77. doi: 10.11648/j.iji.20160406.15
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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