Volume 4, Issue 1, February 2016, Page: 1-5
Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon
George Mondinde Ikomey, Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon
Atashili Julius, Department of Public Health, Faculty of Health Sciences, University of Buea, Buea, Cameroon
Graeme Brendon Jacobs, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
Martha Tongo Mesembe, Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon
Agnes Eyoh, Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon
Emilia Lyonga, Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon
Okomo Assoumou Marie Claire, Departement of Microbiology/Immunology, Faculty of Medicine and Biomedical Sciences University of Yaounde, Yaounde, Cameroon
Received: Nov. 21, 2015;       Accepted: Nov. 29, 2015;       Published: Mar. 22, 2016
DOI: 10.11648/j.iji.20160401.11      View  4076      Downloads  201
Abstract
sFas (CD95) / FasL are hallmarks of apoptosis involvement in pathogenesis of HIV. We assess changes in soluble Fas /FasL, CD4 % and HIV-1 viral load in patients prior to the initiation of antiretroviral therapy (ART) and 6 months thereafter. A prospective longitudinal study on sixty consented HIV-1 positive adults. sFas and sFasL levels were measured by ELISA. CD4 cell counts and HIV-1 viralloads were measured using standard methods. Samples were analysed according to the manufacturers’ guidelines.There was a significant positive correlation between HIV-1 viral load and FasL at six months (M6) on treatment [r = +0.49, (0.03)]. There were no correlation between sFas/FasL and CD4 cell counts [ r = -33 (0.16), -31 (0.17) -23 (0.03) respectively]. The significant correlation between sFasL and HIV-1 viral load at six months of ART suggests that sFasL could be a signal biomarker for HIV-1 disease progression. We have shown in this study that high levels of sFasL depict high HIV-1 viral loads and advance state of the HIV disease. These biomarker should be investigated further in other settings.
Keywords
sFasligands (CD95), Apoptosis, HIV, AICD, ART
To cite this article
George Mondinde Ikomey, Atashili Julius, Graeme Brendon Jacobs, Martha Tongo Mesembe, Agnes Eyoh, Emilia Lyonga, Okomo Assoumou Marie Claire, Fas Mediated(CD95L) Periferal T-cell Apotosis Marker in Monitoring HIV-1 Disease Progression in Adults in Yaoundé, Cameroon, International Journal of Immunology. Vol. 4, No. 1, 2016, pp. 1-5. doi: 10.11648/j.iji.20160401.11
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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