Volume 3, Issue 3, June 2015, Page: 42-46
Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior
Magdy Abdullah Sayedelahl, Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Naser Nagib Nasr, Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Mahmoud Hamed Akr, Department of Otorhinolaryngology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Dina Sayed Sheha, Department of Internal Medicine, Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Tahany Mohamed Rabie, Department of Otorhinolaryngology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Received: Jun. 8, 2015;       Accepted: Jun. 18, 2015;       Published: Jul. 2, 2015
DOI: 10.11648/j.iji.20150303.13      View  4091      Downloads  90
Abstract
Background: A randomized single-blinded study including 50 patients with allergic rhinitis. Objective: To evaluate and compare the efficacy of subcutaneous versus sublingual immunotherapy in treatment of allergic rhinitis. Materials and methods: Patients divided into Group A: twenty patients received subcutaneous immunotherapy and group B: twenty patients received sublingual immunotherapy for twelve months. We assessed skin prick test, symptom score and medication use, quality of life and nasal smear eosinophilic count before and after treatment. Results: In group A, clinical improvement was achieved in 100% of monosensitised and 62.5% of polysensitised patients, while in group B 100% of monosensitised and 60% of of polysensitised patients exhibited clinical improvement. Conclusion: The subcutaneous and sublingual routes of immunotherapy have similar efficacy.
Keywords
Allergen Specific Immunotherapy, SCIT, SLIT, Allergic Rhinitis, Skin Prick Test, Nasal Smear Eosinophilia, Clinical Improvement
To cite this article
Magdy Abdullah Sayedelahl, Naser Nagib Nasr, Mahmoud Hamed Akr, Dina Sayed Sheha, Tahany Mohamed Rabie, Subcutaneous versus Sublingual Immunotherapy for Allergic Rhinitis therapy: Which Is Superior, International Journal of Immunology. Vol. 3, No. 3, 2015, pp. 42-46. doi: 10.11648/j.iji.20150303.13
Reference
[1]
Tahamiler R, Saritzali G, Canakcioglu S, Ozcora E, Dirican A. Comparison of the long-term efficacy of subcutaneous and sublingual immunotherapies in perennial rhinitis. ORL J Otorhinolaryngol Relat Spec. 2008; 70(3) 144-150.
[2]
Walker, S. M., Durham, S. R., Till, S. J., Roberts, G., Corrigan, C. J., Leech, S. C., Krishna, M. T et al. Immunotherapy for allergic rhinitis. Clinical & Experimental Allergy 2011; 41: 1177–1200
[3]
Pipet A, Botturi K, Pinot D, Vervloet D, Magnan A. Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy. Respir Med. 2009; 103:800–812.
[4]
Canonica GW, Passalacqua G. Non injection routes for immunotherapy. J Allergy Clin Immunol 2003: 111: 437–48.
[5]
Antu´ nez C, Mayorga C, Corzo JL, Jurado A, Torres MJ. Two year follow-up of immunological response in mite-allergic children treated with sublingual immunotherapy. Comparison with subcutaneous administration. Pediatr Allergy Immunol 2008: 19: 210–218.
[6]
Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010; 126:466–476.
[7]
Dreborg S. Histamine reactivity of the skin. Allergy 2001; 56:359-64.
[8]
Kapp A, Demarteau N. Cost effectiveness of levocetirizine in chronic idiopathic urticaria: A pooled analysis of two randomised controlled trials. Clin Drug Investig. 2006; 26:1–11.
[9]
Juniper EF, Thompson AK, Ferrie PJ, Roberts JN. Development and validation of the mini Rhinoconjunctivitis Quality of Life Questionnaire ClinExp Allergy 2000;30:132–140
[10]
Canonica GW, Baena-Cagnani CE, Bousquet J, Bousquet PJ, Lockey RF, Malling HJ et al. Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. Allergy 2007; 62:317–324.
[11]
Crobach M, Hermans J, Kaptein A, Kaptein A, Ridderikhoff J, Mulder J. Nasal smear eosinophilia for the diagnosis of allergic rhinitis and eosinophilic non-allergic rhinitis. Scand J Prim Health Care 1996;14:116-121
[12]
Joint Task Force on Practice Parameters. Allergen immunotherapy: a practice parameter. American Academy of Allergy, Asthma and Immunology. American College of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol. 2003; 90:1–40.
[13]
Cox L, Li JT, Nelson H, et al. Allergen immunotherapy: A practice parameter - second update. J Allergy Clin Immunol 2007; 120: S25-85
[14]
Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study. J Allergy Clin Immunol 2005; 115: 1184-8.
[15]
Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 2010; 125:S103-115
[16]
Kleine-Tebbe J, Ribel M, Herold D. Safety of a standardised grass allergen tablet for sublingual immunotherapy a randomized, placebo-controlled trial,” Allergy 2006; 61(2): 181–184.
[17]
Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005; 60:4-12.
[18]
Passalacqua G, Durham SR. Allergic Rhinitis and its Impact on Asthma update: Allergen immunotherapy. Journal of Allergy and Clinical Immunology 2007;119 (4):881 - 891
[19]
Radulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev 2010; 12:CD002893.
[20]
Kim KW, Kim EA, Kwon BC, Kim ES, Song TW, Sohn MH et al. Comparison of allergic indices in monosensitized and polysensitised patients with childhood asthma. J Korean Med Sci 2006; 21:1012-6.
[21]
Wachholz PA, Durham SR. Mechanisms of immunotherapy: IgG revisited. Curr Opin Allergy Clin Immunol 2004 4(4):313-8.
[22]
Eifan O, Akkoc T, Yildiz A, Keles S, Ozdemir C, Bahceciler NN et al. Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized controlled trial. Clinical & Experimental Allergy 2010; 40:922–932.
[23]
Frew AJ. Allergen immunotherapy. J Allergy Clin Immunol 2010 125: S306-313.
[24]
Khinchi M. S, Poulse L. K, Carat F, André C, Hansen AB, Malling HJ. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy 2004: 59: 45–53.
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