Volume 3, Issue 1, February 2015, Page: 7-13
H. Pylori Prevalence and Its Effect on CD4+ Lymphocyte Count in Active Pulmonary Tuberculosis Patients at Hospitals in Jimma, Southwest Ethiopia
Wakjira Kebede, Department of Laboratory sciences and Pathology, Collage of Public Health and medical sciences, Jimma University, Jimma, Ethiopia; Department of Immunology and Molecular Biology, School of Biomedical and Laboratory sciences, Collage of Medical sciences, University of Gondar, Gondar, Ethiopia
Biniam Mathewos, Department of Immunology and Molecular Biology, School of Biomedical and Laboratory sciences, Collage of Medical sciences, University of Gondar, Gondar, Ethiopia
Gemeda Abebe, Department of Laboratory sciences and Pathology, Collage of Public Health and medical sciences, Jimma University, Jimma, Ethiopia
Received: Feb. 2, 2015;       Accepted: Feb. 27, 2015;       Published: Mar. 3, 2015
DOI: 10.11648/j.iji.20150301.12      View  2778      Downloads  203
Abstract
Background: Helicobacter pylori, a lifelong and typically asymptomatic infection of the stomach, strongly alter gastric immune responses. The present study aimed to survey the prevalence and related risks of H. pylori infection among tuberculosis (TB) patients at hospitals in Jimma City, Southwest Ethiopia. Methods: Comparative cross sectional study was conducted from February to June, 2014. Fifty four PTB patients and an equal number of non TB controls were enrolled. Convenient sampling technique was used to select the study participants. Structured questionnaire was used to collect socio demographic and clinical data. The stool for H. pylori antigen detection and venous blood for CD4+ lymphocyte count was collected. Results: Among 108 study participants, 62 (57.4%) was females. Majority of the study participants, 48 (44.4%) were in the age group of 18-34 years and the mean age of the participants was 37.5 ± 10.7 SD. The prevalence of H. pylori infection among TB patients and non TB controls were 19 (35.2%) and 11 (20.4%), respectively. TB patients with CD4+ lymphocyte count of less than 200Cells/mm3 was more likely to be infected. Conclusion: H. pylori infection among TB patients was significantly higher than non TB controls. Low CD4+ lymphocyte count was found to be associated with high H. pylori infection among TB patients. Further study should be undertaken to reveal the potential pathogenic mechanisms for underlying associations for H. pylori and TB infection.
Keywords
H. pylori, Pulmonary Tuberculosis, CD4+ Lymphocyte, Jimma
To cite this article
Wakjira Kebede, Biniam Mathewos, Gemeda Abebe, H. Pylori Prevalence and Its Effect on CD4+ Lymphocyte Count in Active Pulmonary Tuberculosis Patients at Hospitals in Jimma, Southwest Ethiopia, International Journal of Immunology. Vol. 3, No. 1, 2015, pp. 7-13. doi: 10.11648/j.iji.20150301.12
Reference
[1]
Anastasios R, Nikiforos P, Konstantinos IG: Helicobacter pylori infection and respiratory diseases: a review. WJG 2003, 9(1):5-8.
[2]
Dorji D, Dendup T, Malaty HM, Wangchuk K, Yangzom D, Richter JM: Epidemiology of Helicobacter pylori in Bhutan: The Role of Environment and Geographic Location. Helicobacter 2013(Electronic 1523):53-75.
[3]
Hunt RH, Xiao SD, Megraud F, Leon-Barua R, Bazzoli F, van der Merwe S, al. e: Helicobacter pylori in developing countries. World Gastroenterology Organization Global Guidelines 2010.
[4]
Neumann WL, Coss E, Rugge M, Genta RM: Autoimmune atrophic gastritis--pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol 2013, 10(9):529-541.
[5]
Shrestha S, Paudel P, Pradhan GB, Shrestha L, Bhattachan CL: Prevalence study of H. pylori infection in dyspeptic patients coming to Nepal Medical College Teaching Hospital, Jorpati, Kathmandu. Nepal Med coll J 2012, 14(3):229-233.
[6]
Katayoon N, Masoud S, Saeed F MS, Masoud J: Helicobacter pylori seroprevalence in patients with Bronchiectasis. Tanaffos 2006, 5(3):25-29.
[7]
www.ju.edu.et. Jimma University: 2013.
[8]
Philippou N, Roussos A, Tsimpoukas F, Anastasakou E, Mavrea S, Tsimogianni A: Helicobacter pylori infection in patients with active pulmonary tuberculosis before the initiation of anti-tuberculosis treatment. Anals of Gastroenterology 2003, 16(1):49-52.
[9]
Cheesbrough M: District Laboratory Practice in Tropical countries. United States of America New York: Cambridge University press; 2006.
[10]
Salman H, Sabine RG: MGITprocedure manual prepared for the foundation for Inovativies New diagnostics 2006.
[11]
Veijola L, Myllyluom E, Korpela R, Rautelin H: Stool antigen tests in the diagnosis of Helicobacter pylori infection before and after eradication therapy. WJG 2005, 11(46):7340-7344.
[12]
Ashgar SS: Helicobacter Pylori Diagnosis by Stool Antigen ELISA and Rapid Test. J Applied Medical Sciences 2013, 2(4):61-66.
[13]
Hosmer DW, Lemesshow S, Strurdivant RX: Appliedlogestic regression USA: Johan wiley and sons 2013.
[14]
Maria N, Dulciene M, Rodrigo T, Andreia MC, Manuel B, Lucia L: Helicobacter pylori Infection in Adults from a Poor Urban Community in Northeastern Brazil: Demographic, Lifestyle and Environmental Factors. The Brazilian J of infectious disease 2005, 9(5):405-410.
[15]
Torres MA, Passaro DJ, Watanabe J, Parsonnet J, Small P, Miyagui J, Rodriquez C, Astete M, Gilman RH: No association between Helicobacter pylori and Mycobacterium tuberculosis infections among gastrointestinal clinic attendees in Peru Epidemiol Infect 2003(130):87-91.
[16]
Buskin SE, Weiss NS, Gale JL, Nolan CM: Tuberculosis in relation to a history of peptic ulcer disease and treatment of gastric hyperacidity. American journal of epidemiology 1995, 141(3):218-224.
[17]
Pawlowski A, Jansson M, Sko¨ld M, Rottenberg ME, Kallenius G: Tuberculosis and HIV Co-Infection. Plos pathog 2012, 8(2):e1002464.
[18]
Altamann DM, Sansom D, Marshi SG: What is the basis for HLA-DQ association with Authoimmune disease. Immunology Today 1991, 12(8):267-270.
[19]
Goldfled AE, Delgado JC, Thim S, Bozona V, Uglialoro AM, Turbay D ea: Association of an HLA-DQ allele with Clinical Tuberculosis. JMA 1998, 279(3):226-228.
[20]
Brighenti S, Andersson J: Local Immune Responses in Human Tuberculosis: Learning From the Site of Infection. JID 2012, 205(2):316-324.
[21]
Affusim C, Abah V, Kesieme EB, Anyanwu K, EifediyiR: TheEffectofLowCD4+LymphocyteCounton theRadiographicPatternsofHIVPatientswithPulmonary TuberculosisamongNigerians. Tuber Rese and Treat2013, 4:1-4.
[22]
Shams-Hosseini SN, Javad Mousavi SA, Kadivar M, Ahmadipour E, Yazdani R, Moradians V: Helicobacter Pylori in Patients Suffering from Pulmonary Disease. Tanaffos 2011 10(1):31-36.
[23]
Kebede W, Keno F, Ewunetu T: Acceptance of Provider Initiated HIV Testing and Counseling among Tuberculosis Patients in East Wollega Administrative Zone, Oromia Regional State, Western Ethiopia. Tuber Rese and Treat 2014, 5:1-5.
[24]
World health organization: Global tuberculosis report. 2012.
[25]
Hestvik E, Tylleskar T, Ndeezi G, Grahnquist L, Olafsdottir E, Tumwine JK, et al: Prevalence ofHelicobacter pyloriin HIV-infected, HAART-naïve Ugandan children: a hospital-based survey. Journal of the International AIDS Society 2011, 14(34):1-9.
[26]
Taddesse G, Desta K, Esayas S, Bane A: Association of dyspepsia symptoms and Helicobacter pylori infections in private higher clinic, Addis Ababa, Ethiopia. EMJ 2011, 49(2):109-116.
Browse journals by subject